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OALib Journal期刊

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Risk factors for morbidity and death in non-cystic fibrosis bronchiectasis: a retrospective cross-sectional analysis of CT diagnosed bronchiectatic patients
Pieter Goeminne, Hans Scheers, Ann Decraene, Sven Seys, Lieven Dupont
Respiratory Research , 2012, DOI: 10.1186/1465-9921-13-21
Abstract: Adult patients seen at our department between June 2006 and November 2009 were recruited if the key string "bronchiect-" was mentioned in electronic clinical records and if chest CT imaging was available. Clinical records of all patients with confirmed radiologic diagnosis of bronchiectasis were reviewed and clinical characteristics were analyzed.539 patients with a radiographic diagnosis of non-cystic fibrosis bronchiectasis were identified in a retrospective cross-sectional analysis giving a prevalence of 2.6% in our hospital population. A wide range of etiologies was found with idiopathic bronchiectasis in 26%. In the 41 months interval, 57 patients (10.6%) died. We found a median exacerbation rate of 1.94 per year. Bacterial colonization status was associated with more deaths, exacerbation rate, symptoms and reduced pulmonary function. Pulmonary hypertension was found in 48% of our patients.We evaluated a large non-cystic fibrosis bronchiectasis population, and provided new epidemiological data on associations between clinical characteristics and deaths and morbidity in these patients.First described by Rene Theophile La?nnec in 1819, bronchiectasis (BX) are now defined as permanently dilated airways due to chronic bronchial inflammation caused by inappropriate clearance of various microorganisms and recurrent or chronic infection [1,2]. Diagnosing BX has become significantly easier with the advent of high resolution computed tomography (HRCT), which has proved to be highly sensitive for demonstrating bronchiectatic change in the airways [3]. Overall, postinfectious and idiopathic BX are the most frequent cause of non-CF bronchiectasis (NCFB), although the list of potential etiologies is extensive [4-6].In the past, several studies evaluated clinical and microbiological characteristics of this NCFB population [5-13]. Although these studies identified a number of risk factors associated with lung function decline, the populations studied are limited due to referr
IL-17A in Human Respiratory Diseases: Innate or Adaptive Immunity? Clinical Implications
Dominique M. A. Bullens,Ann Decraene,Sven Seys,Lieven J. Dupont
Clinical and Developmental Immunology , 2013, DOI: 10.1155/2013/840315
Abstract:
Immunosuppressive parameters in serum of ovarian cancer patients change during the disease course
Ahmad Kasran,An Coosemans,Annouschka Laenen,Ignace Vergote,Judit Decoene,Sven Seys,Tha?s Baert,Tina Verschuere
- , 2016, DOI: 10.1080/2162402X.2015.1111505
Abstract:
IL-13 is a central mediator of chemical-induced airway hyperreactivity in mice
Benoit Nemery,Fien C. Devos,Jan Ceuppens,Jeroen A. J. Vanoirbeek,Jonathan Cremer,Karel Talavera,Lore Pollaris,Peter H. M. Hoet,Sven Seys,Tomoaki Hoshino
- , 2017, DOI: 10.1371/journal.pone.0180690
Abstract:
Factors Influencing Students’ Preferences to Pursue International Advanced Pharmacy Practice Experiences
Amanda Margolis,Connie Kraus,Trisha Seys Ranola
- , 2018, DOI: https://doi.org/10.24926/iip.v9i1.959
Abstract: Abstract The Problem: To improve the quality of the international APPE program and facilitate growth, a questionnaire was developed to identify perceived barriers for selection of and ways to increase interest in international APPEs. Survey Design: A questionnaire was administered to two consecutive third-year classes to gauge interest, perceived barriers and possible facilitators for engagement in international APPEs. Key Findings: Cost and need to travel independently were most frequently identified as barriers to participating in international APPEs. Suggestions to increase participation in international APPEs include: schools of pharmacy actively developing funding support, pairing students for international APPEs, and earlier targeted marketing. Disclosures: None Type: Not
Lattice Enthalpy Drives Hubbard U to Zero  [PDF]
Sven Larsson
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.46A007
Abstract:

In the equation U = IA for the Mott energy, the electron-hole interaction of the successor state is missing. Adding the attractive term, the energy for disproportionation (Hubbard U), may adopt any sign. The missing term is related to the Born effect, the Madelung correction and the Lattice Enthalpy.

Cyclic Vitalism: The Dialectics of Life and Death in German Poetry around 1900*  [PDF]
Sven Halse
Advances in Literary Study (ALS) , 2014, DOI: 10.4236/als.2014.21004
Abstract:

Over the past decade, Scandinavian and German scholars have been active in the redefinition of the terms “Vitalism” and “Vitalist” as descriptive categories for analytical purposes in the fields of literary and cultural history. In this context,“Vitalism”has primarily been used to describe an enthusiastic worshipping of life, one that holds youth, health, strength and beauty as its primary attributes, which was prevalent in all aspects of cultural life around 1900. But even the post war founders of the Vitalist re-conceptualisation of this era, Wolfdietrich Rasch and Gunter Martens, warned of taking such a unilateral view ofwhat constituted a Vitalist concept of life. It could lead to a misunderstanding of Vitalist way of thinking, Rasch said, if the focus wasonly set upon the enthusiastic surplus, the worshipping of youth and health. To Vitalists, life is more than that. It is a totality that also encompasses notions of destruction, decay and death. “All life symbols in literature around 1900 are at the same time symbols of death” (Rasch, 1967:24).Through the analyses of three poems, this article aims to show concrete examples of how cyclic Vitalist thinking is embedded in poetry of the era. The analyses include a further sub-categorisation to capture the different types of Life Force dealt with in the texts. By way of an introduction, Vitalism is discussed within the context of the scientific and social developments of the 19th Century.

Minimising Excessive Energy Consumption in Schools While Maintaining Optimal Air Quality  [PDF]
Sven Hallin
Open Journal of Optimization (OJOp) , 2017, DOI: 10.4236/ojop.2017.64010
Abstract: This paper presents an assessment of how to minimise excessive energy consumption in a case study school classroom while maintaining optimal indoor air quality. Using mixed method research with qualitative interview data supporting quantitative key data measurements, essential primary data was extracted from temperature and carbon dioxide monitoring equipment in the classroom. This was then used, along with other ancillary data, to develop an IES computer model of the classroom as a “base case” reflecting existing energy consumption, temperatures and CO2 levels. Eight different interventions were then developed and modelled which reflected improved energy supply and a variety of ventilation strategies. The results show that adequate control and design of energy supply systems is critical to minimising excessive energy consumption, and that adequate internal air quality is achievable through a variety of low cost strategies.
An Analytical Portfolio Credit Risk Model Based on the Extended Binomial Distribution  [PDF]
Sven Fischer
Journal of Financial Risk Management (JFRM) , 2019, DOI: 10.4236/jfrm.2019.83012
Abstract:
The binomial distribution describes the probability of the number of successes for a fixed number of identical independent experiments, each with binary out-put. In real life, practical applications like portfolio credit risk management trials are not identical and have different realization probabilities. In addition to the number, the quantitative impacts of the respective outputs are also important. There exist no complete model-side implementations for the expansion of the binomial distribution, especially not in the case of specific quantitative parameters up to now. Here, a solution of this issue is described by the extended binomial distribution. The key for solving the problem lies in the use of bijection between the elementary events of the binomial distribution and the digit sequences of binary numbers. Based on the extended binomial distribution, an analytical portfolio credit risk model is described. The binomial distribution approach minimizes the approximation error in modeling. In particular, the edges of the loss distribution can be determined in a realistic manner. This analytical portfolio credit risk model is especially predestined for management of risk concentrations and tail risks.
Analysis of Biometric Authentication Protocols in the Blackbox Model
Koen Simoens,Julien Bringer,Hervé Chabanne,Stefaan Seys
Computer Science , 2011,
Abstract: In this paper we analyze different biometric authentication protocols considering an internal adversary. Our contribution takes place at two levels. On the one hand, we introduce a new comprehensive framework that encompasses the various schemes we want to look at. On the other hand, we exhibit actual attacks on recent schemes such as those introduced at ACISP 2007, ACISP 2008, and SPIE 2010, and some others. We follow a blackbox approach in which we consider components that perform operations on the biometric data they contain and where only the input/output behavior of these components is analyzed.
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